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The road bike frame is what makes a bike, a bike. The frame is "fits" you, and it's where you hang all of your components from.
A good road bike frame can be made from carbon fiber, aluminum, titanium or steel. This lightweight wonder of engineering will support your weight, and transmit your power to the ground. Different road bike frames have properties that affect handling, feel and fit.
Cyclocross frames are similar to road bike frames but have clearance for larger tires and have brakes that shed mud and snow. A cyclocross frame can make for a great commuting bike, road bike and off-road bike all at once!